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Articoli e novità
Metabolism of magnesium in health and disease.
Magnesium (Mg) is an intracellular
cation. It is an essential element which catalyses more than
300 enzymatic reactions, in particular those involving ATP.
Approximately half of the total Mg in the body is present
intracellularly in soft tissues, and the other half is present
in bone. Serum Mg determination represents only 1% of total
body's Mg concentration. Modern instruments will soon be
available to determine physiologically active intracellular
ionised Mg. Despite the ubiquitous nature of Mg, low serum Mg
occurs either from decreased absorption or due to increased
excretion. Hypomagnesaemia is surprisingly common in hospital
populations and is more prevalent in acute than in chronic
cases but often remains undetected or overlooked. Magnesium
deficiency may result in hypokalaemia and hypocalcaemia.
Myocardial Mg depletion may result in influx of Na+ and Ca+2
into the mitochondria which may lead to myocardial cell death.
Hence, low Mg concentration may be a factor for a wide variety
of clinical conditions.